Senior research associate specialist technical skills

Case Western Reserve University seeks a(n) Senior Research Associate Specialist Technical Skills

in Cleveland, OH.

Duties: Works on a multitude of bioinformatics and biostatistics projects for the Dowlati Lab and Case Comprehensive Cancer Center. Develop, optimize, and execute high quality computational pipelines for data management and analysis. Responsible for statistical analysis of medical record data and integrating inference and predictions from bed to bench. Collaborate with the Clinical Informatics team in the development of a public Small Cell Lung Cancer dashboard. Deploy and use bioinformatic processing pipelines for the integration and analysis of human clinical and multi-omics data from whole exome/genome sequencing, transcriptomic (RNA-Seq) experiments, and other sequencing projects (e.g., ATAC-Seq, ChIP-Seq, methylation assays). Develop protocols, study designs, and extraction-transformation-loading (ETL) pipelines for the lab's ever-growing SCLC patient sequencing databank. Implement and apply machine learning techniques and advanced multivariate statistical methods for responder/non-responder analysis, patient outcome predictions, and other relevant tasks. Develop, optimize, and maintain cloud-based infrastructure for running bioinformatics pipelines extracting data from AWS, Tempus, etc. and analyzing them on the HPC server using shell scripting, following best practices for automation and reproducibility. Continuously learn and implement new bioinformatics and genomics methodologies to address the team's needs. Communicate bioinformatics analysis results effectively with academic and industry partners.

REQUIREMENTS: Master's degree in Biostatistics, Bioengineering, Computational Biology, Systems Biology, or a related field of study and two (2) years of experience as a Research Associate, Graduate Research Assistant, Bioinformatics Technologist, or related role.

Two (2) years of experience with the following: Programming in R and Data science and bioinfomatic packages including Tidyverse, Caret, DESeq2, ClusterProfiler, and TxImport.

One (1) year of experience with the following: NGS analysis including RNA-Seq, ChIP-Seq, Exome-Seq, BS-Seq analysis; bioinformatic tools including XCell, MSigDb, WebGestalt; Navigating online cancer databases including cBioPortal, GEO, and TCGA; Creating pipelines for parallel bioinformatic analyses using High Performance Computer Unix shell scripting and SLURM scheduler; Cloud computing (AWS) and Spatial Sequencing (Loupe Browser); Database Management Systems (DBMS) including PowerBI; and Visualization tools such as Prism or Tableau.

To apply: Email resume to [email protected] and reference: Senior Research Associate Specialist Technical Skills.